Deciphering the intricacies of immune control

August 10, 2026Open Access

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Key Points

The aim is to investigate the mechanisms underlying the loss of self-tolerance in multiple sclerosis and correlates of protection in infectious diseases.
Analyzed the phenotype and interactions of brain-resident CD8+ T cells in multiple sclerosis.
Identified immunological correlates of protection and disease control for HIV and tuberculosis.
Examined transcriptional and cell-based tests for reliable monitoring of tuberculosis treatment success.
Identified persistent MAIT cells and mononuclear phagocytes in early active lesions of MS.
Demonstrated the importance of fine-tuning the sequence and structure of immunogens in developing next-generation HIV vaccines.
Optimized tests for monitoring treatment success in tuberculosis through immunological correlates.

Examines immune control mechanisms in multiple sclerosis, HIV, and tuberculosis, suggesting pathways for improved treatments.

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Kathrin Held (2026) studied this question.

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