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October 1, 1976Journal of HygieneOpen Access

Pathogenesis of foot-and-mouth disease: the lung as an additional portal of entry of the virus

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Population

Experimental cattle exposed to foot and mouth disease (FMD) virus subtype O1

Comparison

Exposure to FMD virus by different routes vs Different routes of exposure

Design

Preclinical

Authors

PSP. SutmöllerAgricultural Research ServiceJMJ. W. McVicarCenters for Disease Control and Prevention

Discussion

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Implication

Hypothesis-generating for FMD pathogenesis in cattle; extends experimental models but leaves open real-world validation.

Structured PICO

P
Population
Experimental cattle exposed to foot and mouth disease (FMD) virus subtype O1
I
Intervention
Exposure to FMD virus by different routes (contact exposure, intranasal inoculation, tracheotomy bypassing pharynx, intravenous route)
C
Comparator
Different routes of exposure
O
Outcome
Pharyngeal virus growth and viraemia patternssurrogate

The study demonstrates that the lower respiratory tract can serve as an additional portal of entry for the foot-and-mouth disease virus in cattle.

Cite This Study

Sutmöller et al. (1976) studied this question.

synapsesocial.com/papers/6a7c29e305df6d7f2ea1595fhttps://doi.org/10.1017/s0022172400024669
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Presence and Persistence of Foot-and-Mouth Disease Virus in Bovine Skin1966 · 47 citations
  2. 2Growth of foot-and-mouth disease virus in the upper respiratory tract of non-immunized, vaccinated, and recovered cattle after intranasal inoculation1976 · 73 citations
  3. 3Further investigations on the airborne excretion of foot-and-mouth disease virus1970 · 105 citations
  4. 4Pathogenesis of foot-and-mouth disease: clearance of the virus from the circulation of cattle and goats during experimental viraemia1976 · 10 citations
  5. 5Contact Transmission of Foot-and-Mouth Disease from Infected to Susceptible Cattle1971 · 33 citations