Precise determination of DNA concentration without the health risks of intercalating dyes is possible via the optical changes that arise from DNA-induced aggregation of cationic conjugated polyelectrolytes. Addition of DNA to a conjugated electrolyte containing two fluorophores results in aggregation and fluorescence quenching, inducing a measurable and quantifiable shift from blue- to green-light emission (see figure and inside cover).
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Hong et al. (2006) studied this question.
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