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Vascularity in normal valves varies by technique; leaves open standardized histological criteria for valve research.
Descriptions of the presence of blood vessels in the valves of human hearts vary. Using routine histological, injection, and clearing techniques, the majority of authors have described vessels in the attached portion of the cusp, but differ on the incidence of this observation and its relation to com- pletely normal histological valve structure. Thus Gross (1921) demonstrated blood vessels in 6 per cent of normal mitral valves from birth until the ninth decade of life, and reported that this finding possibly had some relation to the incidence of endocarditis in the vascularized valves. This view was supported by several authors (Kugel and Gross, 1926; Gross and Friedberg (1936a, b) thought that any vascularized heart valve was probably abnormal.
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J.A. Clarke (1965) studied this question.
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