Population
Male and female Wistar rats with chronic renal failure (CRF) induced by 5/6 nephrectomy, and control rats
Comparison
Castration vs Non-castrated rats (control)
Design
Preclinical
Follow-up
30 days
Authors
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Should not alter CRF management in humans; leaves open gender-specific hormonal effects on glomerular barrier integrity.
Castration reduces renal glycosaminoglycans and proteinuria in male rats with chronic renal failure, suggesting a gender-dependent role of sex hormones in the glomerular filtration barrier.
Lemos et al. (2013) studied this question.
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