Why the study?
Primary mediastinal B-cell lymphoma is a rare non-Hodgkin lymphoma that represents a major diagnostic and therapeutic challenge in malignant hematology.
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Highlights a rare presentation of primary mediastinal B-cell lymphoma as pleuritic chest pain with unusual iliosacral involvement.
Primary mediastinal B-cell lymphoma (PMBCL) is a rare type of diffuse large B-cell lymphoma, constituting 2-4% of non-Hodgkin lymphomas. Here we present a case of PMBCL initially presenting as pleuritic chest pain in an otherwise healthy 33-year-old woman. PMBCL typically presents as a large, fast-growing tumor limited to the mediastinum, making the iliosacral involvement in this case unusual. R-CHOP is the most commonly used chemotherapy regimen, although more aggressive therapies like EPOCH-R can spare the need for consolidative radiation therapy. PMBCL represents one of the greatest diagnostic and therapeutic challenges in malignant hematology.
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Weidenbaum et al. (2022) studied this question.
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