Key result
Statins demonstrate pleiotropic antitumor activity, supporting a potential therapeutic role in lung cancer.
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Review highlights the antitumor mechanisms of statins in lung cancer, indicating potential therapeutic utility in prevention and disease management.
century. Statins as inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase not only reduce the cholesterol levels in the blood and decrease the risk of cardiovascular disease but may also play an important role in the prevention and treatment of lung cancer. Statins have several antitumor properties including the ability to reduce cell proliferation and angiogenesis, decrease invasion and synergistic suppression of lung cancer progression. Statins induce tumor cell apoptosis by inhibition of downstream products such as small GTP-binding proteins, Rho, Ras and Rac, which are dependent on isoprenylation. Statins reduce angiogenesis in tumors by down-regulation of pro-angiogenic factors, such as vascular endothelial growth factor. In this review, the feasibility and efficacy of statins in the prevention and treatment of lung cancer are discussed.
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Amin et al. (2021) conducted a review in Lung cancer. Statins was evaluated. Statins exhibit antitumor properties—inhibiting cell proliferation, angiogenesis, and invasion while inducing apoptosis—suggesting a potential role in lung cancer prevention and treatment.
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