Key result
Higher neutrophil percentage-to-albumin ratio was significantly associated with an increased risk of psychological distress across all participants (OR 4.043), particularly in those with cardiovascular disease.
Why the study?
Inflammation is a shared feature of cardiovascular disease and psychological distress, prompting investigation into the role of the neutrophil percentage-to-albumin ratio in psychological distress associated with CVD comorbidity.
Cross-Sectional (n=3,695)
No
Odds Ratio: 4.043 (95% CI 2.083–7.851)
p-value: p=<0.001
Higher neutrophil percentage-to-albumin ratio (NPAR) is significantly associated with increased odds of psychological distress, particularly in patients with cardiovascular disease.
May identify at-risk cardiovascular patients; hypothesis-generating and should not change practice pending prospective data.
Background Inflammation is a comorbidity of cardiovascular disease (CVD) and psychological distress. The neutrophil percentage-to-albumin ratio (NPAR) has recently been reported as an inflammatory factor. We aimed to assess the role of NPAR in psychological distress associated with CVD comorbidity. Methods Data for the current study were obtained from a cross-sectional research project based in Beijing. All participants were aged ≥ 18 years and completed the questionnaire and hematological examination. Data on CVD, psychological distress, and NPAR were collected. Psychological distress was defined as symptoms of depression combined with anxiety. Univariate and multiple logistic regression analyses were used to assess the relationship between the NPAR and psychological distress. Results A total of 3695 participants (median age, 39 years; 55.67% male) were enrolled in the study. The incidence rates of CVD, psychological distress, and comorbidities of CVD and psychological distress were 16.86%, 6.90%, and 1.35%, respectively. NPAR was a significant risk factor for psychological distress after adjusting for other risk factors in all participants (odds ratio [OR] 4.043, 95% confidence interval [CI] 2.083–7.851; P < 0.001), patients with CVD (OR 7.284, 95% CI 1.428–37.161; P = 0.017), and non-CVD participants (OR 4.896, 95% CI 2.403–9.973; P < 0.001). Conclusion NPAR was associated with psychological distress in all participants, including patients with CVD and participants without CVD. The risk of psychological distress associated with NPAR was higher in participants with CVD than in those without CVD.
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Lu et al. (2023) conducted a cross-sectional in Psychological distress and cardiovascular disease (n=3,695). Neutrophil percentage-to-albumin ratio (NPAR) was evaluated on Psychological distress (symptoms of depression combined with anxiety) (OR 4.043, 95% CI 2.083-7.851, p=<0.001). Higher neutrophil percentage-to-albumin ratio was significantly associated with an increased risk of psychological distress across all participants (OR 4.043), particularly in those with cardiovascular disease.
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