Key result
Higher childhood BMI was associated with higher cf-PWV, SBP, and DBP across all cohorts, and lower birth weight in Angolan children was linked to increased aortic stiffness.
Why the study?
The study was designed to analyze the relationship between early-life indicators, blood pressure, and arterial stiffness in childhood across populations with different bio-cultural characteristics.
Do early-life indicators and BMI correlate with blood pressure and arterial stiffness in children from different bio-cultural backgrounds?
Cross-Sectional (n=520)
Yes
Do early-life indicators and BMI correlate with blood pressure and arterial stiffness in children from different bio-cultural backgrounds?
p-value: p=<0.001
Higher BMI in childhood and lower birth weight are associated with increased arterial stiffness and blood pressure, highlighting the impact of early-life factors on cardiovascular risk.
Hypothesis-generating for early-life factors in arterial stiffness; leaves open whether childhood interventions alter adult CVD risk.
BACKGROUND: To analyze the relationship between early-life indicators, blood pressure (BP), and arterial stiffness in childhood, in three samples with different bio-cultural characteristics. METHODS: The total sample included 520 schoolchildren 9-10 years of age from Madrid (Spain), Vitória (Brazil), and Luanda (Angola). Height and weight, BP, and carotid-femoral pulse wave velocity (cf-PWV) were measured, all by one observer in each site, and body mass index (BMI) was calculated. Birth weight, gestational age, type of feeding, and age at weaning were extracted from official health cards. Data were analyzed by multiple linear regression models. RESULTS: No significant differences were observed in systolic blood pressure (SBP) and diastolic blood pressure (DBP) among the samples (P = 0.107 and P = 0.808). Luanda showed the higher cf-PWV (5.7 m/s), followed by Vitória (5.3 m/s) and Madrid (4.9 m/s; P < 0.001). Explanatory factors for the observed variability in SBP, DBP, and cf-PWV, obtained by means of multiple linear regression models, were different in three samples. BMI showed a positive and significant association with SBP, DBP, and cf-PWV in three samples. In the Angolan sample, in addition to BMI, birth weight was maintained in the explanatory models of SBP and cf-PWV adjusted for BP, with a negative and significant coefficient (-0.019 and -0.019). CONCLUSIONS: Higher values of BMI in childhood are related with higher values of cf-PWV, SBP, and DBP in the three samples. Children from Angola showed the highest mean value of cf-PWV, especially those who had lower birth weight, suggesting that worse conditions in fetal life may contribute to increased aortic stiffness in childhood.
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López et al. (2018) reported a cross-sectional. Body mass index and birth weight was evaluated on Carotid-femoral pulse wave velocity (cf-PWV) and blood pressure (p=<0.001). Higher childhood BMI was associated with higher cf-PWV, SBP, and DBP across all cohorts, and lower birth weight in Angolan children was linked to increased aortic stiffness.
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