We describe the development of the photoswitchable agonist LOGO, which activates GIRK channels in the dark and is rapidly deactivated upon exposure to long wavelength UV irradiation. LOGO can be used to optically silence action potential firing in dissociated hippocampal neurons and exhibits activity in vivo , controlling the motility of zebrafish larvae in a light-dependent fashion.
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Barber et al. (2015) studied this question.
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