Objective: To evaluate various antiplasmodial and anti-inflammatory activities of Setaria megaphylla to authenticate its potential in traditional medicine. Methods: The crude ethanol extract was divided into two portions. Partitioning of one portion into n-hexane, dichloromethane, ethyl acetate and n-butanol fractions was carried out. The suppressive, prophylactic and curative effects of 150, 300, 450 mg/kg of the remaining extract portion were evaluated, while suppressive and curative activities were evaluated at 300 mg/kg of each of the above mentioned fractions. Artesunate and pyrimethamine at doses of 5 mg/kg and 1.2 mg/kg respectively were the standard drugs. Gas chromatography mass spectroscopy (GC-MS) was used to perform a qualitative analysis of dichloromethane and n-butanol fractions which had the highest antiplasmodial activity. Antipyretic effect of Setaria megaphylla extract was investigated using the D-amphetamine, 2,4-dinitrophenol and yeastinduced pyrexia models with ASA (100 mg/kg) as standard drug.
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Udobang et al. (2017) studied this question.
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