Key result
Whole genome sequencing (WGS) identified the co-circulation of multiple subtypes of enterovirus A71 genotype C, including novel recombinants, in Denmark in 2016.
Observational
Highlights the need for whole genome sequencing to detect and characterize emerging, potentially highly pathogenic enterovirus A71 strains.
Highlights the clinical utility of genomic surveillance for detecting emerging pathogens; leaves open whether these novel enterovirus.
In Europe, enterovirus A71 (EV-A71) has primarily been associated with sporadic cases of neurological disease. The recent emergence of new genotypes and larger outbreaks with severely ill patients demonstrates a potential for the spread of new, highly pathogenic EV-A71 strains. Detection and characterisation of these new emerging EV variants is challenging as standard EV assays may not be adequate, necessitating the use of whole genome analysis.
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Midgley et al. (2017) conducted an observational in Enterovirus A71 (EV-A71) infection. Whole genome sequencing (WGS) was evaluated. Whole genome sequencing (WGS) identified the co-circulation of multiple subtypes of enterovirus A71 genotype C, including novel recombinants, in Denmark in 2016.
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