Why the study?
Does Trypanosoma cruzi infection inhibit the differentiation of L6E9 rat myoblasts into myotubes?
Does Trypanosoma cruzi infection inhibit the differentiation of L6E9 rat myoblasts into myotubes?
Trypanosoma cruzi infection directly inhibits the morphological and biochemical differentiation of muscle cells in vitro, providing insight into the molecular pathology of Chagas disease myopathy.
L6E9 rat myoblasts were infected in tissue culture with the myotropic Brazil strain of Trypanosoma cruzi. The effect of parasite infection on the ability of myoblasts to differentiate into myotubes was studied. Both morphological and biochemical differentiation were found to be profoundly affected by parasitic infection in a dose-related fashion. Evidence is presented to suggest that infected myoblasts can no longer differentiate. Differentiation, once underway, seemed unaffected by the parasitic infection; biochemical markers of differentiation remained intact.
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Rowin et al. (1983) studied this question.
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