Key result
Perioperative catecholamine administration in adult cardiac surgery was associated with increased major cardiac morbidity (30% vs. 9%; unadjusted OR 4.2, 95% CI 2.5-7.3; P<0.001).
Why the study?
Does perioperative use of catecholamines increase major cardiac morbidity in adult patients undergoing cardiac surgery?
Cohort (n=657)
Does perioperative use of catecholamines increase major cardiac morbidity in adult patients undergoing cardiac surgery?
Odds Ratio: 4.2 (95% CI 2.5–7.3)
Absolute Event Rate: 30% vs 9%
p-value: p=<0.001
Perioperative use of dobutamine in cardiac surgery is associated with increased major cardiac morbidity, suggesting it should be used only when benefits clearly outweigh risks.
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Associated with increased morbidity in this cohort; leaves open causality and requires randomized confirmation before practice change.
Fellahi et al. (2008) conducted a cohort in Cardiac surgery (n=657). Catecholamines (mainly dobutamine) vs. No catecholamines (control group) was evaluated on Major cardiac morbidity (ventricular arrhythmia, use of an intraaortic balloon pump and postoperative myocardial infarction) (OR 4.2, 95% CI 2.5-7.3, p=<0.001). Perioperative catecholamine administration in adult cardiac surgery was associated with increased major cardiac morbidity (30% vs. 9%; unadjusted OR 4.2, 95% CI 2.5-7.3; P<0.001).
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