Key result
RAC2 subunit genotypes TA/AA were significantly associated with anthracycline-induced cardiotoxicity in elderly patients with aggressive B-cell lymphoma (OR 2.3; p=0.028).
Why the study?
Are NADPH oxidase polymorphisms associated with an increased risk of anthracycline-induced cardiotoxicity in elderly patients with aggressive CD20+ B-cell lymphoma?
Observational
Are NADPH oxidase polymorphisms associated with an increased risk of anthracycline-induced cardiotoxicity in elderly patients with aggressive CD20+ B-cell lymphoma?
Odds Ratio: 2.3
p-value: p=0.028
RAC2 and CYBA polymorphisms of NADPH oxidase are associated with an increased risk of anthracycline-induced cardiotoxicity in elderly lymphoma patients, supporting a genetic predisposition to this adverse event.
May aid risk stratification in elderly lymphoma patients; hypothesis-generating pending prospective validation.
AIM: To identify gene variants responsible for anthracycline-induced cardiotoxicity. PATIENTS & METHODS: Polymorphisms of the NADPH oxidase subunits and of the anthracycline transporters ABCC1, ABCC2 and SLC28A3 were genotyped in elderly patients (61-80 years) treated for aggressive CD20(+) B-cell lymphomas with CHOP-14 with or without rituximab and followed up for 3 years. RESULTS: The accumulation of RAC2 subunit genotypes TA/AA among cases was statistically significant upon adjustment for gender, age and doxorubicin dose in a multivariate logistic regression analysis (OR: 2.3, p = 0.028; univariate: OR: 1.8, p = 0.077). RAC2 and CYBA genotypes were significantly associated with anthracycline-induced cardiotoxicity in a meta-analysis of this and a similar previous study. CONCLUSION: Our results support the theory that NADPH oxidase is involved in anthracycline-induced cardiotoxicity. Original submitted 9 July 2014; Revision submitted 19 December 2014.
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Reichwagen et al. (2015) conducted an observational in Aggressive CD20(+) B-cell lymphoma. RAC2 subunit genotypes TA/AA was evaluated on Anthracycline-induced cardiotoxicity (OR 2.3, p=0.028). RAC2 subunit genotypes TA/AA were significantly associated with anthracycline-induced cardiotoxicity in elderly patients with aggressive B-cell lymphoma (OR 2.3; p=0.028).
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