The combination of perphenazine-amitriptyline was compared to each of its constituents in a double-blind study conducted with 138 depressed and anxious-depressed neurotic outpatients. Irrespective of drug, general practice patients improved the most, clinic patients somewhat less, and private psychiatric patients the least. Drug differences were limited to a few significant and borderline-significant effects present only at two weeks; they indicated that perphenazine produced the greatest improvement at this period.
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DeSILVERIO et al. (1970) studied this question.
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