Key result
In vitro modeling of endothelial dysfunction using different cell cultures is a useful tool for developing methods to improve endothelial function and evaluate the effects of medicinal products.
Why the study?
In vivo analysis of endothelial cellular regulation is limited by their vascular localization, making in vitro modeling of endothelial dysfunction a valuable approach.
In vitro models of endothelial dysfunction, particularly using HUVEC and other cell lines, provide crucial insights into the molecular mechanisms of cardiovascular diseases and potential therapeutic targets.
May advance preclinical endothelial research; leaves open clinical translation.
Endothelial dysfunction is universally regarded as one of the key elements in the pathogenesis of most of cardiovascular diseases including ischemic heart disease, atherosclerosis, arterial hypertension, myocardial infarction, stroke, dilated cardiomyopathy, as well as diabetes mellitus, inflammatory, oncological, and autoimmune diseases. Localization of endothelial cells in tunica intima of the vessels limits in vivo analysis of the intracellular proteins and other molecules, which regulate cellular functional activity. A possible solution to this problem may be setting experimental conditions for physiological and pathological functioning of endothelial cells. In vitro modeling of endothelial dysfunction may be a useful tool for the development of methods to improve the endothelial function and evaluate the effects of medicinal products. The objective of this literature review is to summarize main trends in studying endothelial dysfunction in vitro using different endothelial cell cultures.
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Kalinin et al. (2019) conducted a review in Endothelial dysfunction. In vitro modeling of endothelial dysfunction was evaluated. In vitro modeling of endothelial dysfunction using different cell cultures is a useful tool for developing methods to improve endothelial function and evaluate the effects of medicinal products.
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