Mechanism and New Findings in Brugada Syndrome
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Population
Patients with Brugada syndrome and experimental models
Design
Review
Authors
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Implication
Requires prospective validation before guiding Brugada management; leaves open targeted research on testosterone and SCN5A haplotypes.
Structured PICO
P
Population
Patients with Brugada syndrome and experimental models (arterially perfused canine right ventricular wedge preparations)
This review highlights that Brugada syndrome's arrhythmogenesis is driven by epicardial phase 2 reentry, with male predominance linked to higher testosterone levels and Asian prevalence associated with a specific SCN5A promoter haplotype.
Cite This Study
Shimizu et al. (2007) studied this question.
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