August 1, 1998The Journal of PhysiologyOpen Access

Absence of viscerosomatic inhibition with injections of lobeline designed to activate human pulmonary C fibres

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Why the study?

Does intravenous lobeline induce viscerosomatic inhibition of motor performance in human subjects?

Population

Human subjects

Follow-up

Immediate (seconds)

Authors

SGSimon C. GandeviaUniversity of Delhi JBJane E. ButlerThe University of Sydney JTJanet L. TaylorEdith Cowan University

Discussion

Member takes

Implication

Pulmonary C-fiber activation does not inhibit motor performance; leaves open the J reflex's role in limiting exercise.

Structured PICO

Does intravenous lobeline induce viscerosomatic inhibition of motor performance in human subjects?

Population

Human subjects

Intervention

Intravenous bolus injections of lobeline (suprathreshold doses, 37-73 microgram kg-1)

Outcome

Presence of reflex or descending inhibition of motoneuronal output (measured via H reflex in soleus, EMG responses, force production, and walking)surrogate

Activation of pulmonary C fibres with lobeline does not cause viscerosomatic inhibition of motor performance in humans, casting doubt on the J reflex's role in limiting exercise.

Cite This Study

Gandevia et al. (1998) studied this question.

synapsesocial.com/papers/6a7c65edd96db32555401119 https://doi.org/10.1111/j.1469-7793.1998.289bi.x

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Absence of viscerosomatic inhibition with injections of lobeline designed to activate human pulmonary C fibres

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Absence of viscerosomatic inhibition with injections of lobeline designed to activate human pulmonary C fibres

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider