Key result
Enhancement of cardiac lymphangiogenesis plays an important role in modulating interstitial edema, inflammation, and fibrosis, offering a potential therapeutic avenue for cardiovascular regeneration.
Why the study?
To review the structure and function of cardiac lymphatics in cardiovascular diseases and explore the therapeutic potential of cardiac lymphangiogenesis in cardiac repair and regeneration.
Enhancing cardiac lymphangiogenesis represents a potential therapeutic strategy for improving cardiac recovery after myocardial infarction or in heart failure.
May identify lymphangiogenesis as a regenerative target in heart disease; hypothesis-generating and requires clinical validation.
This article highlights the importance of the structure and function of cardiac lymphatics in cardiovascular diseases and the therapeutic potential of cardiac lymphangiogenesis. Specifically, we explore the innate lymphangiogenic response to damaged cardiac tissue or cardiac injury, derive key findings from regenerative models demonstrating how robust lymphangiogenic responses can be supported to improve cardiac function, and introduce an approach to imaging the structure and function of cardiac lymphatics.
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Xu et al. (2023) conducted a review in Cardiovascular diseases. Therapeutic lymphangiogenesis was evaluated. Enhancement of cardiac lymphangiogenesis plays an important role in modulating interstitial edema, inflammation, and fibrosis, offering a potential therapeutic avenue for cardiovascular regeneration.
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