Colchicine injected intravenously into pregnant hamsters on the 8th day of gestation at levels of 10 mg kg produces a fetal mortality of 50%. Gross congenital malformations, consisting of microphthalmia, anophthalmia, umbilical hernia, exencephaly, and skeletal anomalies are found in a significant number of survivors.
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Vergil H. Ferm (1963) studied this question.
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