Key result
HOMA-IR cutoffs near ~3.0 identify insulin resistance in pubertal and postpubertal adolescents.
Cross-Sectional (n=80)
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Objective: To validate the homeostasis model assessment (HOMA) of insulin resistance (IR) as a surrogate to the hyperglycemic clamp to measure IR in both pubertal and postpubertal adolescents, and determine the HOMA-IR cutoff values for detecting IR in both pubertal stages. Subjects and methods: The study sample comprised 80 adolescents of both sexes (aged 10-18 years; 37 pubertal), in which IR was assessed with the HOMA-IR and the hyperglycemic clamp. The optimal cutoff values of the HOMA-IR for detecting IR were > 3.22 (sensitivity, 85.7; 95% CI, 57.2-98.2; specificity, 82.6; 95% CI, 61.2-95.0) for pubertal and > 2.91 (sensitivity, 63.6; 95% CI, 30.8-89.1, specificity, 93.7; 95%CI, 79.2-99.2) for postpubertal adolescents. Conclusion: The threshold value of the HOMA-IR for identifying insulin resistance was > 3.22 for pubertal and > 2.91 for postpubertal adolescents.
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Silva et al. (2022) conducted a cross-sectional in Insulin resistance (n=80). Homeostasis model assessment of insulin resistance (HOMA-IR) vs. Hyperglycemic clamp was evaluated on Detection of insulin resistance (p=< 0.001). HOMA-IR identified insulin resistance at optimal cutoffs of >3.22 for pubertal (sensitivity 85.7%, specificity 82.6%) and >2.91 for postpubertal adolescents (sensitivity 63.6%, specificity 93.7%).
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