Key result
Ultrasonographically measured visceral fat thickness was independently and significantly associated with serum levels of chemerin (β=0.23, p=0.008) and resistin (β=0.43, p=0.002).
Why the study?
Obesity status can be assessed with numerous anthropometric, morphological, and functional indices, and the study was designed to investigate the relationships among them, including ultrasonographic fat measurements and proinflammatory adipokines.
Does ultrasonographically measured visceral fat tissue thickness correlate with proinflammatory adipokine levels in obese individuals?
Cross-Sectional (n=80)
Does ultrasonographically measured visceral fat tissue thickness correlate with proinflammatory adipokine levels in obese individuals?
Ultrasonographically measured visceral fat thickness is independently associated with proinflammatory adipokine levels (chemerin and resistin) in obese individuals.
Visceral fat thickness may mark adipokine-driven inflammation in obesity; leaves open causal and prognostic value for cardiometabolic risk.
Background/Aim. Obesity status can be assessed with numerous anthropometric, morphological and functional indices and this study was designed to assess relationship among them. The aim of this study was to investigate associations between anthropometric indices, ultrasonography measurement of visceral and subcutaneous fat tissue thickness and certain proinflammatory adipokines level. Methods. This cross-sectional study comprised a consecutive sample of 60 obese respondents without obesity-related comorbidities, and 20 age-matched healthy normal-weight controls. Anthropometric [body mass index (BMI), waist circumference (WC), neck circumference (NC), body fat, a body shape index (ABSI)], and ultrasonographic indices [thickness of intraabdominal fatt tissue (IAFT), visceral fat (VF), maximum subcutaneous fat (Max SFT), minimal subcutaneous fat (Min SFT)], and serum levels of chemerin and resistin were assessed in all subjects. Results. All anthropometric indices showed statistically significant differences between study groups. The mean IAFT, Max SFT, Min SFT and VF were significantly higher in the obese group compared to controls (p < 0.01, for all). Serum levels of chemerin and resistin correlated positively with BMI, percentage of fat adipose tissue (FAT, %), total FAT (kg), and VF (p < 0.05, for all). Also, we observed significant correlation between resistin and NC (r = 0.23, p = 0.03) and ABSI (r = 0.22, p = 0.04). In multivariable linear regression analysis, chemerin (? = 0.23; p = 0.008) and resistin (? = 0.43; p =0.002) were independently and significantly associated only with VF. Conclusion. Obesity indices, both classical and newer ones, are in positive, statistically significant correlation with the level of proinflammatory cytokines. Ultrasonographically measured VF thickness, independently associated with adipokine levels, may improve assessment of proinflammatory fat tissue characteristics. Further studies are needed to precisely define the use of ultrasonographic fat tissue measurements into clinical practice.
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Crnobrnja et al. (2018) conducted a cross-sectional in Obesity (n=80). Visceral fat tissue thickness vs. Normal-weight controls was evaluated on Association of visceral fat with proinflammatory adipokines (chemerin and resistin) (β = 0.23 for chemerin; β = 0.43 for resistin, p=0.008 for chemerin; 0.002 for resistin). Ultrasonographically measured visceral fat thickness was independently and significantly associated with serum levels of chemerin (β=0.23, p=0.008) and resistin (β=0.43, p=0.002).
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