Laboratory study demonstrates ultra-sensitive detection of sperm DNA damage using a CRISPR-Cas12a biosensor, highlighting potential utility in clinical reproductive medicine.
This study presents a highly sensitive fluorescence biosensor integrating TdT enzyme and CRISPR-Cas12a for precise detection of sperm DNA damage, achieving a detection limit of 0.99 pM and a linear range of 0.001-0.2 nM. Its exceptional sensitivity, simplicity, and versatility make it a transformative tool for reproductive medicine and clinical diagnostics.
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Wang et al. (2025) studied this question.
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