Answers are grounded in this paper and cite their sources.
Gene delivery with cationic liposomes formed from the diamine-lipid DC-Chol and the neutral lipid DOPE has proven successful. New polyamine analogues of DC-Chol have been synthesised, formulated into cationic liposomes with DOPE and biologically tested in vitro and in vivo in mouse lung. Cationic liposomes containing the novel DC-Chol analogue CTAP (shown below) work 100 times more effectively in vivo than DC-Chol containing liposomes (500 times better than DNA alone) and therefore should be suitable for use in human gene therapy approaches towards lung disorders and other clinical conditions.
No takes yet. Share an insight, caveat, or question.
Cooper et al. (1998) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: