Ferroptosis: a new approach for immunotherapy

CD8 + T cells have become the central focus of novel cancer therapeutics. A recent report by Wang et al. in Nature identified that activated CD8 + T cells could induce tumor cell ferroptosis through the generated interferon-γ, which attenuated the glutamate–cystine antiporter system xc- and contributed to lipid peroxidation and ferroptosis. This novel observation suggested that CD8 + T cells initiated the tumor cell’s ferroptosis.