SUMMARY The primary and secondary responses of rats to SRBC, measured by means of haemolytic antibody titres, showed strain differences. High‐responder strains produced high levels of antibodies of IgG and IgM. Low‐responder strain produced only low level of IgM antibody. With subsequent antigen challenge, only the high‐responder strains produced high titres of antibody. Low‐responder strain, in contrast, continued to make a low level of IgM antibody. Allogeneic transfer of spleen cells changed the low‐responder strain, Fischer rats, to produce anti‐SRBC IgG antibody. Fischer rats also showed low responses to OVA, BGG and to some ‘thymus independent antigens’. Genetic analyses showed the antibody production against SRBC and BGG was controlled by a single gene respectively. No linkage was found between Ir‐SRBC, Ir‐BGG, R (major histocompatibility) and c (coat colour) loci.
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Tada et al. (1974) studied this question.
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