Key result
Protein kinase C isoforms act as key regulators of cardiac contraction, hypertrophy, and ischemic/reperfusion injury, providing potential targets for the development of novel therapeutics.
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Design
Review
May guide PKC-targeted drug development in cardiac disease; leaves open clinical translation pending isoform-specific trials.
Protein kinase C (PKC) isoforms have emerged as important regulators of cardiac contraction, hypertrophy, and signaling pathways that influence ischemic/reperfusion injury. This review focuses on newer concepts regarding PKC isoform-specific activation mechanisms and actions that have implications for the development of PKC-targeted therapeutics.
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Susan F. Steinberg (2012) studied this question. Protein kinase C isoforms act as key regulators of cardiac contraction, hypertrophy, and ischemic/reperfusion injury, providing potential targets for the development of novel therapeutics.
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