Investigates the role of O-glycosylation and tyrosine sulfation on thrombin binding, suggesting post-translational modifications tune anticoagulant activity.
Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.
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Hsieh et al. (2011) studied this question.
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