Why the study?
Current treatments for pulmonary hypertension target pathways controlling pulmonary vascular tone and proliferation, but have limited efficacy on patient outcomes.
Design
Review
Key result
This review highlights key pathophysiological concepts and emerging therapeutic directions for pulmonary arterial hypertension, targeting inflammation, cellular metabolism, genetics, and epigenetics.
Authors
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Review highlights emerging PH therapies; leaves open their efficacy in diverse populations without dedicated RCTs.
This review summarizes the complex pathophysiology of pulmonary arterial hypertension and highlights emerging therapeutic targets beyond traditional pulmonary vasodilator pathways.
Bousseau et al. (2023) conducted a review in Pulmonary hypertension. This review highlights key pathophysiological concepts and emerging therapeutic directions for pulmonary arterial hypertension, targeting inflammation, cellular metabolism, genetics, and epigenetics.