Key result
Review proposes a unifying hypothesis linking glycemic control and genetics in diabetic microvascular complications.
Answers are grounded in this paper and cite their sources.
Two hypotheses have been advanced to explain the appearance of microvascular complications in diabetic patients with glycemic control. The genetic hypothesis suggests that the development of diabetic complications is genetically determined and independent of diabetic control, whereas the metabolic hypothesis suggests that long-term hyperglycemia causes the subsequent development of small-blood-vessel complications. We review data that either support or reject these hypotheses and suggest a third unifying hypothesis.
No takes yet. Share an insight, caveat, or question.
Raskin et al. (1986) conducted a review in Diabetes with microvascular complications. Glycemic control / long-term hyperglycemia was evaluated on Development of diabetic microvascular complications. Glycemic control and genetic factors are reviewed regarding their roles in diabetic microvascular complications to propose a third unifying hypothesis (no quantitative data reported).
Synapse has enriched 10 related papers. Consider them for comparative context: