Key result
Beta-fibrinogen -455A haplotype linked to higher fibrinogen levels and increased atherothrombotic risk.
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Common polymorphisms of the fibrinogen gene cluster are associated with circulating fibrinogen level and with susceptibility to and/or severity of atherothrombotic disease. The frequencies of the polymorphisms vary among different ethnic groups but there is strong linkage disequilibrium at the beta-fibrinogen gene locus so that, in caucasian populations, there are only four common beta-fibrinogen haplotypes. One of these haplotypes, defined by the beta-fibrinogen -455A allele, is associated with elevated fibrinogen level and increased risk of atherothrombotic disease. The molecular mechanism of these associations is currently under investigation.
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F.R. Green (2001) conducted a review in Atherothrombotic disease. Beta-fibrinogen -455A allele haplotype vs. Other common beta-fibrinogen haplotypes was evaluated on Circulating fibrinogen level and risk of atherothrombotic disease. The beta-fibrinogen -455A allele haplotype (one of four common haplotypes in Caucasian populations) is associated with elevated fibrinogen levels and increased risk of atherothrombotic disease.
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