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September 1, 1991Antimicrobial Agents and ChemotherapyOpen Access

Activity of pentamidine and pentamidine analogs against Toxoplasma gondii in cell cultures

David S. Lindsay Byron L. Blagburn James Edwin Hall Richard R. Tidwell

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Abstract

The capabilities of pentamidine and nine pentamidine analogs to inhibit the development of Toxoplasma gondii were examined in vitro. Treatment of infected cultures with pentamidine and five of its analogs caused a significant (P less than 0.05) reduction in the numbers of tachyzoites produced. Analogs of pentamidine may be useful agents in the treatment of toxoplasmosis.

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Lindsay et al. (1991) studied this question.

synapsesocial.com/papers/6a7c938d0d1c97f421a8ad2b https://doi.org/10.1128/aac.35.9.1914

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