Key result
Innate and adaptive immune mechanisms bidirectionally modulate chronic inflammatory atherosclerosis pathogenesis.
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There is now overwhelming experimental and clinical evidence that atherosclerosis is a chronic inflammatory disease. Lessons from genome-wide association studies, advanced in vivo imaging techniques, transgenic lineage tracing mice, and clinical interventional studies have shown that both innate and adaptive immune mechanisms can accelerate or curb atherosclerosis. Here, we summarize and discuss the pathogenesis of atherosclerosis with a focus on adaptive immunity. We discuss some limitations of animal models and the need for models that are tailored to better translate to human atherosclerosis and ultimately progress in prevention and treatment.
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A 2019 study conducted a review in Atherosclerosis. Innate and adaptive immune mechanisms was evaluated. Innate and adaptive immune mechanisms can accelerate or curb the pathogenesis of chronic inflammatory atherosclerosis, though no quantitative clinical data were reported in this review.
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