EXPRESSION OF TGF-beta-1 mRNA AND ULTRASTRUCTURAL ALTERATIONS IN PHARMACOLOGICALLY INDUCED PROLONGED PENILE ERECTION IN A CANINE MODEL

No AccessJournal of UrologyInvestigative Urology1 Dec 1998EXPRESSION OF TGF-beta-1 mRNA AND ULTRASTRUCTURAL ALTERATIONS IN PHARMACOLOGICALLY INDUCED PROLONGED PENILE ERECTION IN A CANINE MODEL MAQSOOD UL-HASAN, AHMED EL-SAKKA, I. CELESTE LEE, TIEN-SZE YEN, B. RAJVIR DAHIYA, and TOM LUEF. MAQSOOD UL-HASANMAQSOOD UL-HASAN , AHMED EL-SAKKAAHMED EL-SAKKA , CELESTE LEECELESTE LEE , TIEN-SZE YENTIEN-SZE YEN , RAJVIR DAHIYARAJVIR DAHIYA , and TOM LUETOM LUE View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)62307-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Transforming growth factor beta (TGF-beta) is known to induce fibrosis. Our objective was to study the role of TGF-beta as a possible mediator of fibrosis that may follow prolonged penile erection. Materials and Methods: Prolonged penile erection was induced in seven adult male mongrel dogs by intracavernosal injection of papaverine into one of the corpora cavernosa while the other was used as a control. Intracavernosal pressure measurements were carried out prior to administration of papaverine and at the end of the procedure. Penile tissue was collected from anesthetized animals prior to euthanasia for histological and electron microscopic (EM) studies. RT-PCR was carried out for detection of mRNA on same tissue samples. Results: The light microscopy showed stasis of blood in the cavernosal sinusoids. EM studies revealed sporadic endothelial defects, loss of plasma membrane integrity and cytoplasmic condensation. There was expression of TGF-beta 1 mRNA in 66.7% of the experimental group compared with 16.7% of the control group. 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Google Scholar 50 : Natural inhibitor of transforming growth factor beta protects against scarring in experimental kidney disease. Nature1992; 360: 361. Google Scholar From the Department of Urology, University of California, San Francisco, CA 94143-0738© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byBURNETT A (2018) Pathophysiology of Priapism: Dysregulatory Erection Physiology Thesis.Journal of Urology, VOL. 170, NO. 1, (26-34), Online publication date: 1-Jul-2003. Volume 160Issue 6 Part 1December 1998Page: 2263-2266 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information MAQSOOD UL-HASAN More articles by this author AHMED EL-SAKKA More articles by this author CELESTE LEE More articles by this author TIEN-SZE YEN More articles by this author RAJVIR DAHIYA More articles by this author TOM LUE More articles by this author Expand All Advertisement PDF downloadLoading ...