Reversible Dynamic Left Ventricular Outflow Tract Obstruction in Two Young Dogs Managed with β₁-Blockers

Q: What is the clinical evidence from this study?

Study design: Case Report. Population: Dynamic left ventricular outflow tract obstruction (n=2). Intervention: Beta-1 blockers (Atenolol). Primary outcome: Echocardiographic resolution of left ventricular outflow tract obstruction and left ventricular hypertrophy.

Hyung‐Kyu Chae; Won-Kyoung Yoon

doi:10.17555/jvc.2025.42.2.102

April 30, 2025Journal of Veterinary ClinicsOpen Access

Reversible Dynamic Left Ventricular Outflow Tract Obstruction in Two Young Dogs Managed with β₁-Blockers

View Full Paper

Ask AI

Bookmark

Share

Why the study?

Due to a lack of reported cases, it is difficult to determine whether DLVOTO resolution in young dogs is driven by aging-related architectural changes or beta-blocker therapy.

Does atenolol reduce left ventricular outflow tract obstruction and left ventricular hypertrophy in young dogs with DLVOTO?

Study Design

Type

Case Report (n=2)

Structured PICO

Does atenolol reduce left ventricular outflow tract obstruction and left ventricular hypertrophy in young dogs with DLVOTO?

P

Population

Two young female dogs (5 and 8 months old) with dynamic left ventricular outflow tract obstruction managed with beta-1 blockers.

I

Intervention

Atenolol (beta-1 adrenergic antagonist) 0.5 to 1 mg/kg oral every 12 hours.

O

Outcome

Echocardiographic changes associated with DLVOTO (LVOT Vmax velocity) and consequent left ventricular concentric hypertrophy (IVSd, LVPWd).surrogate

Beta-1 adrenergic antagonists (atenolol) can effectively reduce left ventricular outflow tract obstruction and secondary left ventricular hypertrophy in young dogs with DLVOTO.

Limitations

Difficult to determine the exact cause of DLVOTO as post-mortem autopsy was not possible.
Lack of studies on the association between echocardiographic improvements and clinical symptoms or long-term benefits.
Absence of a control group makes it difficult to definitively rule out age-related changes in ventricular architecture.
Difficult to determine the exact cause of DLVOTO
Post-mortem autopsy was not possible
Lack of studies on the association between echocardiographic improvements and clinical symptoms/benefits

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

DLVOTO case reports in young dogs warrant caution before attributing resolution to beta-blockers; leaves open treatment versus age-related effects.

Abstract

Dynamic left ventricular outflow tract obstruction (DLVOTO) is commonly observed in feline patients with hypertrophic cardiomyopathy, but it is less frequent in dogs.DLVOTO observed in young dogs often resolves after 1 -adrenergic antagonist treatment.However, due to the lack of reported cases and the absence of a control group, it is difficult to determine whether improvements are due to aging-related changes in ventricular architecture or treatment itself.Thus, we report two cases of DLVOTO confirmed via echocardiography.Case 1 was an 8-month-old female Spitz and Case 2 was a 5-month-old female Cocker Spaniel.A prophylactic 1 -adrenergic antagonist was prescribed to reduce the outflow gradient, and echocardiographic changes associated with DLVOTO and consequent left ventricular concentric hypertrophy resolved after 1 -blocker prescription.This is the first report to discuss echocardiographic changes in relation to changes in -blocker dose in canine DLVOTO.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Chae et al. (2025) conducted a case report in Dynamic left ventricular outflow tract obstruction (n=2). Beta-1 blockers (Atenolol) was evaluated on Echocardiographic resolution of left ventricular outflow tract obstruction and left ventricular hypertrophy.

synapsesocial.com/papers/6a7c9704f1688b70c0610f8e https://doi.org/10.17555/jvc.2025.42.2.102

View Full Paper

Ask AI

Bookmark

Share

Reversible Dynamic Left Ventricular Outflow Tract Obstruction in Two Young Dogs Managed with β₁-Blockers

Study Design

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Reversible Dynamic Left Ventricular Outflow Tract Obstruction in Two Young Dogs Managed with β₁-Blockers

Study Design

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading