All articles of this category A novel transformation of primary amines to the corresponding N -monoalkylhydroxylamines is described. The three-step protocol involves selective mono-cyanomethylation of primary amines, regioselective formation of nitrones by m -CPBA oxidation, and hydroxylaminolysis of the nitrones with hydroxylamine hydrochloride. The method is applicable for a wide range of primary amines, including alkyl, benzyl, and chiral. amine - hydroxylamine - oxidation - cyanomethylation - nitrone
No takes yet. Share an insight, caveat, or question.
Tokuyama et al. (2000) studied this question.