Alleviating Impact of Taurine on Renal Lipid Peroxidation and Oxidative Stress in Lambda-Cyhalothrin Exposed Rat

BackgroundLambda-cyhalothrin (LCT) is an isomeric form of the two biologically active diastereoisomeric pairs of cyhalothrin, containing an alpha-cyano group. Taurine or 2-aminoethane sulfonic acid is a sulfur-containing α-amino acid that is the most abundant free amino acid in most mammal tissue. Aim and ObjectivesThe present study was focused to investigate lambda-cyhalothrin induced nephrotoxicity and renal oxidative stress as well as to evaluate the alleviating role of taurine in this condition. MethodsLambda-cyhalothrin was administered orally at two dose levels (10.83 and 15.17 mg/kg body weight) alone or in combination after pre-treatment of taurine (50 mg/kg body weight) for consecutive 14 days. ResultsRenal toxicity was measured by a significant decrease in renal index, reduction in kidney protein and an increase in serum protein in lambda-cyhalothrin intoxicated rats. At the same time, lambda-cyhalothrin induced a significant renal oxidative stress demonstrated by elevated renal malondialdehyde content and oxidized glutathione level accompanied by a reduction in reduced glutathione and antioxidant enzymes in rats. Lambda-cyhalothrin induced renal toxicity and oxidative stress in the rat was significantly ameliorated due to the administration of taurine as an antidote. ConclusionAll of these findings of the present study strongly suggest the protective role of taurine in the pathophysiology of lambda-cyhalothrin-induced renal toxicity and oxidative stress.