The combined effects of radiations and halogenophenols were investigated. The activities of these reagents to increase the radiolethality during irradiation were demonstrated with E. coli and Z. soya. Some relationships between chemical structure and activity were revealed as follows at pH 6 and 8: (1) effectiveness of substituted halogen was in the order of I>Br>Cl; (2) effectiveness of the monosubstituting position on a benzene ring of halogenophenols was increased in the order of p->m->o-; (3) effectiveness increased with increasing the number of halogen atom. The halogenophenol action was also found to be considerably pH-dependent. In the case of chlorinated derivatives, the synergistic activity to increase the radiolethality was intensified on the acidic side, though bromides and iodides were more effective on the basic side.
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MATSUYAMA et al. (1963) studied this question.