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The role of systemic inflammation in neurodegeneration is complex. It involves interplay between several pro-inflammatory and anti-inflammatory factors, DNA damage and a cycle of neurotoxic inflammation and tissue degradation. Neuroinflammation can trigger neurodegeneration. Though suppressing systemic inflammation might be assumed to be neuroprotective against neurodegeneration, inhibiting certain features of the systemic immune response may cause damage.
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Alireza G. Senejani (2019) studied this question.
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