Polycyclic Aromatic Hydrocarbons as Components of Coal Tar: Assessment of Occupational Risks and Biological Role (A Review)

Polycyclic aromatic hydrocarbons (PAHs) are the predominant chemical compounds in coal tar (CT). Extensive published data indicate their carcinogenic effects both on humans, in industrial workers, and on animals. However, there is a trend toward using CT as a medication for skin diseases, dermatitis, and psoriasis. But how safe is the use of CT for humans? This review systematizes data on the carcinogenic effects of PAHs on humans, their concentrations in coal tar, and the degree of exposure to carcinogenic factors during skin disease therapy.