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May limit post-arrest myocardial depression in dogs; leaves open translation to human cardiac surgery.
Recent studies have demonstrated that prolonged induced cardiac arrest is followed by myocardial damage¹,²and depressed ventricular function³in the dog. It has also been shown that this depression may be limited by prophylactic digitalization⁴and by hypothermia.⁵' The present communication reports our experiences with the use of mephentermine sulfate (Wyamine), a cardiotonic and pressor agent,⁶in dogs in which myocardial function has been depressed by a 30-minute period of asystole induced by potassium citrate. Methods Mongrel dogs of 8.5 to 12.5 kg. body weight were used. Anesthesia was induced by intravenous thiopental sodium. Complete respiratory paralysis was obtained with intravenously administered succinylcholine. The animals were respired⁷with 100% oxygen at pressures of 15 to 20 cm. water. Esophageal temperature was recorded by a thermistor probe. Femoral arterial pressure was measured by means of a P23A Statham transducer. Arterial blood was sampled by way
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Theodore Cooper (1959) studied this question.
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