This minireview series summarizes mechanisms of bimodal targeting of different types of proteins and their pathophysiological consequences. Two reviews discuss mechanisms of targeting of drug inducible cytochrome P450s to endoplasmic reticulum and mitochondria. The third review discusses mechanisms of fumerase and other cystosolic soluble proteins to mitochondria and the cytosol and the fourth review discusses the mitochondrial localization of cytosolic glutathione S-transferases
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Narayan G. Avadhani (2011) studied this question.
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