Chlordecone (CLD) is an organochlorine pesticide that is highly resistant in the environment. This compound and its metabolite chlordecol (CLD-OH) still can be found in the French West Indies, after being banned 30 years ago. The novelty of this work lies in evaluating the toxicity of CLD-OH compared to CLD and examining the effects of these compounds on nuclear receptor ( PXR , PPARα , and CAR ) and metabolism-related genes ( CYP2B6 , CYP3A4 ) in vitro using HepG2 cell line as a model. Our study demonstrates that both compounds displayed an almost similar pattern of decrease in cell viability. Moreover, it was shown that CLD-OH can increase the expression of PXR , CYP3A4 , and PPARα genes in comparison to CLD. The AKR1C4 gene showed a slight decrease in expression after CLD treatment. Collectively, this study provided a new finding into the impact of CLD-OH and compares the mode of action of CLD and its metabolite . • Comparison of the impact of Chlordecol to the impact of Chlordecone on detoxification gene using HepG2 cells as model. • Chlordecone and its metabolite have similar pattern of decrease in cell viability. • Chlordecol can increase the expression of PXR , CYP3A4 , and PPARα genes. • The AKR1C4 gene showed a slight decrease in expression after chlordecone treatment.
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Baratzhanova et al. (2025) studied this question.
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