What question did this study set out to answer?

To develop and validate a low-cost mortality risk estimation score for surgical intensive care unit patients using routine laboratory parameters measured at admission.

January 1, 2008European Surgical Research

Estimation of the Mortality Risk of Surgical Intensive Care Patients Based on Routine Laboratory Parameters

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Why the study?

Does the DELAWARE score based on routine laboratory parameters accurately predict in-hospital mortality in surgical intensive care patients compared to established risk models?

Population

554 surgical intensive care patients, mean age 61.3 years and 63.1 years.

Comparison

DELAWARE risk score vs Established risk models (APACHE II, SAPS II)

Design

Cohort

Follow-up

in-hospital

Authors

ASAxel StachonWestpfalz Klinikum ABAndreas BeckerGoethe University Frankfurt THTim Holland‐LetzGerman Cancer Research Center

Discussion

Member takes

Implication

May support low-cost mortality risk estimation from routine labs in surgical ICU; leaves open prospective validation against APACHE II or SAPS II.

Key Points

To develop and validate a low-cost mortality risk estimation score for surgical intensive care unit patients using routine laboratory parameters measured at admission.
Derived a risk score in a study sample (n = 271) and evaluated performance in an independent validation sample (n = 283) of surgical intensive care patients.
Used stepwise logistic regression to select routine admission blood parameters and age to construct the Dense Laboratory Whole Blood Applied Risk Estimation (DELAWARE) score.
Assessed discriminative ability using receiver operating characteristic analysis and compared performance against APACHE II and SAPS II scores.
In-hospital mortality was 24.7% (67/271) in the derivation cohort and 23.3% (66/283) in the validation cohort.
The DELAWARE score (incorporating age, ALT, CRP, cholesterol, CK-MB, leukocytes, potassium, thrombocytes, and triglycerides) achieved an AUC of 0.853 in the derivation sample and 0.813 in the validation sample.
DELAWARE scores correlated significantly with APACHE II (r = 0.586) and SAPS II (r = 0.614; p < 0.001) in the study sample.

Structured PICO

Does the DELAWARE score based on routine laboratory parameters accurately predict in-hospital mortality in surgical intensive care patients compared to established risk models?

Population

554 surgical intensive care patients (study sample n=271, validation sample n=283), mean age 61.3 years (study) and 63.1 years (validation).

Intervention

DELAWARE risk score (based on routine laboratory parameters at admission: alanine aminotransferase, C-reactive protein, cholesterol, creatine kinase MB, leukocytes, potassium, thrombocytes, triglycerides, and age)

Comparator

Established risk models (APACHE II, SAPS II)

Outcome

In-hospital mortalityhard clinical

A new risk score (DELAWARE) based solely on routine laboratory parameters at admission can feasibly estimate mortality risk in surgical intensive care patients.

Cite This Study

Stachon et al. (2008) studied this question.

synapsesocial.com/papers/6a7cb6cd3dbea9de8161191f https://doi.org/10.1159/000113106

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Implication

May support low-cost mortality risk estimation from routine labs in surgical ICU; leaves open prospective validation against APACHE II or SAPS II.

Estimation of the Mortality Risk of Surgical Intensive Care Patients Based on Routine Laboratory Parameters

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Estimation of the Mortality Risk of Surgical Intensive Care Patients Based on Routine Laboratory Parameters

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider