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The emergence of depression, parkinsonism, and akathisia after neuroleptic therapy was associated with increased length of hospital-stay in schizophrenics with affective heredity only. In schizophrenics with schizophrenic heredity, increased length of hospital-stay was associated with residual hallucinations and apathy. In the former patients, findings were theoretically attributed to a putative biogenetic abnormality sensitive to the effects of neuroleptic drugs.
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Galdi et al. (1988) studied this question.
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