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October 28, 2020TheranosticsOpen Access

5HFeC NPs sensitively differentiated and accurately localized vulnerable atherosclerotic plaques in ApoE-/- mice via MPI/FLI/CTA, with high MPI and FLI signals observed in the abdominal aorta.

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Why the study?

Does 5HFeC NPs improve the detection of vulnerable atherosclerotic plaques in ApoE-/- mice?

Population

ApoE-/- atherosclerosis mouse model and MPO-implanted C57BL/6J mice

Comparison

5-HT-Fe3O4-Cy7 nanoparticles administered… vs Fe3O4-Cy7 nanoparticles or PBS control

Design

Preclinical

Follow-up

up to 168 hours post-injection

Authors

WTWei TongHHHui HuiWSWenting Shang

Discussion

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Overview

A novel multimodal imaging agent, 5HFeC NPs, successfully targeted active MPO to identify vulnerable atherosclerotic plaques in a preclinical mouse model using MPI, FLI, and CTA.

Structured PICO

Does 5HFeC NPs improve the detection of vulnerable atherosclerotic plaques in ApoE-/- mice?

P
Population
ApoE-/- atherosclerosis mouse model (8-week-old male ApoE-/- mice on high-fat and high-cholesterol diet for 40-42 weeks) and MPO-implanted C57BL/6J mice
I
Intervention
5-HT-Fe3O4-Cy7 nanoparticles (5HFeC NPs) administered intravenously
C
Comparator
Fe3O4-Cy7 nanoparticles or PBS control
O
Outcome
Detection and localization of vulnerable atherosclerotic plaques via MPI/FLI/CTA by targeting active MPOsurrogate

A novel multimodal imaging agent, 5HFeC NPs, successfully targeted active MPO to identify vulnerable atherosclerotic plaques in a preclinical mouse model using MPI, FLI, and CTA.

Cite This Study

Tong et al. (2020) studied this question.

synapsesocial.com/papers/6a7cc024e98c86b2617cd394https://doi.org/10.7150/thno.49812
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