Primary extranodal marginal zone B-cell lymphoma (EMZL) of the female genital tract is a clinical indolent disease. A 61-year-old woman presenting with vaginal prolapse underwent a vaginal hysterectomy and anterior colporrhaphy. Histological examination of the uterus revealed lymphocytic infiltration of the endometrium. The immunohistochemical profile was not in accordance with any known reactive lymphocytic proliferation. Additional polymerase chain reaction and fluorescence in situ hybridization established the diagnosis of EMZL. After staging workup, it was classified as Ann-Arbor stage 1E. Therefore, no adjuvant therapy was needed. Incidental finding of EMZL in the endometrium is exceptional. The asymptomatic presentation is according to the indolent character of extranodal marginal zone lymphoma.
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Heeren et al. (2008) studied this question.