Why the study?
Hyperstimulation of the immune system could lead to autoimmunity, prompting investigation into the link between SARS-CoV-2 vaccination and autoimmune responses.
Does mRNA based anti-SARS-CoV-2 vaccination induce de novo autoantibodies in healthcare workers?
Does mRNA based anti-SARS-CoV-2 vaccination induce de novo autoantibodies in healthcare workers?
Answers are grounded in this paper and cite their sources.
Repeated doses of mRNA-based SARS-CoV-2 vaccines may be associated with a dose-dependent onset of de novo autoantibodies in healthcare workers, suggesting a potential mechanism for autoimmunity that requires further study.
ANA in 22/77(28,57%) of subjects and that the percentage of positivity seems to be directly correlated to the number of vaccine expositions: 6/77 (7,79%) after 2 doses; 16/77 (20,78%) after 3 doses. Since it is known that hyperstimulation of the immune system could lead to autoimmunity, these preliminary results seem to further sustain the idea that the hyperstimulation of the immune system might lead to an autoinflammatory mechanism and eventually to autoimmune disorders. However, the link between SARS-CoV-2 vaccination and the development of autoimmune diseases needs to be further investigated.
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Sacchi et al. (2023) studied this question.
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