Animal study demonstrates that cinnabarinic acid alleviates metabolic dysfunction-associated steatohepatitis in diet-fed mice, highlighting the therapeutic role of hepatic AhR-AMPK signaling.
The study showed that the absence of AhR in hepatocytes results in exacerbated metabolic dysfunction-associated steatohepatitis (MASH) in mice subjected to a Western-style high-fat, high-fructose, high-cholesterol diet. Moreover, treatment with a tryptophan catabolite, cinnabarinic acid (CA), mitigated hallmarks of MASH in an AhR-dependent manner. In conclusion, the study delineates the significance of hepatic AhR-dependent AMPK signaling in CA-mediated protection against MASH.
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Patil et al. (2025) studied this question.
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